PSA has a half-life in the bloodstream of 2 or 3 days. So, if one's PSA level before surgery was 10 ng/mL, as an example, it would take seven half-lives before the PSA fell into the undetectable range (for standard PSA test) of less than 0.1 ng/ml. Example: * start, 10ng/mL. * 1st half-life, down to 5 ng/mL. Research shows a promising new option for men who experience rising PSA after a radical prostatectomy. Many men who undergo surgical treatment for prostate cancer (a radical prostatectomy) live out their lives without a recurrence of their disease. But 20% to 40% of them will experience a rise in prostate-specific antigen (PSA) levels within 10 Abstract. Almost from the time of its discovery, the prostate specific antigen (PSA) has been one of the most accurate and most extensively studied indicators of prostate cancer (PC). Because of advancements in biosensing systems and technology, PSA analysis methods have been substantially updated and enhanced as compared to their first instances. Ultra-sensitive PSA assays also lead to an earlier detection of biochemical relapse than clinical relapse, and this early detection may lead to an improvement in the efficacy of SRT as a therapeutic option. However, conventional imaging investigations such as bone scan and computed tomography of the chest, abdomen, and pelvis have been very PSA was <0.01 ng/mL in 93.4% of the 623 men who did not experience biochemical recurrence (BCR); 30.5% of the 131 men who did have BCR had a PSA ≥0.01 ng/mL. Postoperative PSA at a .01-ng/mL cutoff was shown to independently predict risk of BCR in addition to pathological stage and Gleason score, and surgical margins. I'm 62 years old and have a PSA of 3.1 up from 2.1 two years ago. Urologist has suggested getting a biopsy since prostate cancer is in my family (but all much later in age). I suffer from chronic prostatitis and have had a recent flare-up that has lasted 3 months now. PSA was rechecked 5 weeks after the first one and still at 3.1. Ok, my lab was doing the <.01 sensitivity and I get it done monthly. As of Oct. - lab started to go down to .xxx . Oct and Nov --- .006 Dec test comes back and is <.015 Interpretive Data. After radical prostatectomy, the reference interval is less than 0.05 ng/mL if there is no residual disease. In healthy individuals without prostatectomy, the reference interval is 4.00 ng/mL or less. Lower limit of detection is 0.01 ng/mL. The Roche PSA electrochemiluminescent immunoassay is used. The ZERO Prostate Cancer Support Community connects patients, families, friends and caregivers to enhance the quality of life for all those affected by prostate cancer. Labcorp has an ultra sensitive test that will go to .006 before it reaches undetectable. It's the one I prefer and was recommended by Snuffy Myers several years ago. It detected my rising PSA at its earliest stage last year and allowed me to qualify for Provenge treatment when it is the most effective - when you have a low PSA. AD2PGt.